In Press

Truong, H.H., De Sonneville, J., Ghotra, V.P.S., Xiong, J., Price, L.S., Hogendoorn, P.C.W., Spaink, H., Van de Water, B., Danen, E.H.J. , Automated Microinjection of Cell-Polymer Supsensions in 3D ECM Scaffolds for High Throughput Quantitative Cancer Invasion Screens, Biomaterials.

Qin, Y., Yan, K., Ramaiahgari, S., Verbeek, F., De Graauw, M., Van de Water, B., Price, L.S. , Cyclic AMP signalling protects proximal tubular epithelial cells from cisplatin-induced apoptosis via activation of Epac, Br J Pharmacol.

Qin, Y., Alderliesten, M.C., Stokman, G., Beggs, H., Dworniczak, B., De Heer, E., Ichimura, T., De Graauw, M., Price, L.S., Van de Water, B. , Focal Adhesion Kinase Signaling Mediates Acute Renal Injury Induced by Ischemai/Reperfusion, Am J Path.

2011

Yan, K., Larios, E., Le Dévédec, S., Van de Water, B., Verbeek, F.J. , Automation in Cytomics: Systematic Solution for Image Analysis and Management in High Throughput Sequences., Proceedings IEEE Conf. Engineering and Technology, vol. Vol 7, Shanghai , pp. 195-198.

Fredriksson, L.E., Herpers, B.H.A., Benedetti, G., Matadin, Q., Puigvert, J.C., de Bont, H., Dragovic, S., Vermeulen, N.P.E., Commandeur, J.N.M., Danen, E., de Graauw, M., Van de Water, B. , Diclofenac inhibits tumor necrosis factor alpha-induced nuclear factor-kappaB activation causing synergistic hepatocyte apoptosis, Hepatology, vol. 53, issue 6, pp. 2027-2041.

Stokman, G., Qin, Y., Genieser, H.G., Schwede, F., de Heer, E., Bos, J.L., Bajema, I.M., van de Water, B., Price, L.S. , Epac-Rap Signaling Reduces Cellular Stress and Ischemia-induced Kidney Failure, Journal of the American Society of Nephrology, vol. 22, issue 5, pp. 859-872.

Zhang, Y., Moerkens, M., Ramaiahgari, S., De Bont, H., Price, L., Meerman, J., Van de Water, B. , Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes , Breast Cancer Research , vol. 13, issue R52, pp. 1-16.

Van Roosmalen, W., Le Dévédec, S.E., Zovko, S., De Bont, H., Van de Water, B. , Functional screening with a live cell imaging based random cell migration assay., Methods Mol Biol, vol. 769, pp. 435-48..

Damiano, L., Le Dévédec, S.E., Di Stefano, P., Repetto, D., Lalai, R., Truong, H., Xiong, J.L., Danen, E., Yan, K., Verbeek, F.J., Attanasio, F., Van de Water, B., Defillippi, P. , p140Cap suppresses the invasive properties of highly metastatic MTLn3-EGFR cells via impaired cortactin phosphorylation., Oncogene, issue July.

Hendriks, G., Atallah, M., Raamsman, M., Morolli, B., van der Putten, H., Jaadar, H., Tijdens, I, Esveldt-van Lange, R., Mullenders, L., van de Water, B., Vrieling, H. , Sensitive DsRed fluorescence-based reporter cell systems for genotoxicity and oxidative stress assessment, Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, vol. 709-710, pp. 49-59.

Le Dévédec, S.E., Van Roosmalen, W., Pont, C., Lalai, R., De Bont, H., Van de Water, B. , Two-photon intravital multicolour imaging to study metastatic behaviour of cancer cells in vivo, Methods Mol Biol. 2011, vol. 769, pp. 331-49.

2010

Graauw, M.d., Miltenburg, M.H.A.M.v., Schmidt, M.K., Pont, C.M., Lalai, R., Kartopawiro, J.:Pardali, Le Dévédec, S.E., Smit, V.T., van Wal, A.d., Van 't Veer, L.J., Cleton-Jansen, A.M., Ten Dijke, P., van de Water, B. , Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells., Proc.Natl.Acad.Sci.USA, vol. 107, issue 14, pp. 6.

Verissimo, C.S., Molenaar, J.J., Meerman, J., Puigvert, J.C., Lamers, F., van Kuik-Romeijn, P., Danen, E.H.J., van de Water, B., Versteeg, R., Fitzsimons, C.P., Vreugdenhil, E. , Exploring a new therapy for neuroblastoma; silencing of doublecortin-like kinase using RNA-interference, Neuro Oncology, vol. 12, pp. 64-64.

Carreras-Puigvert, J., Bont, H., Van de Water, B., Danen, E. , High-throughput live cell imaging of apoptosis, Curr.Protoc.Cell.Biol., vol. Chapter 18, issue Unit 18, pp. 1-13.

Danen, E.H.J., van Water, B.d., Carreras-Puigvert, J., Von Stechow, L., Siddappa, R., Mullenders, L., Vrieling, H. , Mapping DNA damage response through RNAi screening and systems approach, Drug Metabolism Reviews, vol. 42, pp. 99.

Van de Water, B., Huijskens, I, Jonker, M., Breit, T., Vrieling, H. , Predictieve Gene-expression Signatures of Non-Genotoxic Carcinogen Responses in Mouse Embryonic Stem Cells, Drug Metabolism Reviews, vol. 42, pp. 54-55.

Le Dévédec, S.E., Yan, K.:Bont, Ghotra, V., Truong, H., Danen, E.H.J., Verbeek, F., Van de Water, B. , Systems Microscopy Approaches to Understand Cancer Cell Migration and Metastasis, Cell.Mol.Life.Sci., vol. 67, issue 19, pp. 3219-3240.

Verissimo, C.S., Molenaar, J.J., Meerman, J., Puigvert, J.C., Lamers, F., Koster, J., Danen, E.H., van de Water, B., Versteeg, R., Fitzsimons, C.P., Vreugdenhil, E. , Silencing of the microtubule-associated proteins doublecortin-like and doublecortin-like kinase-long induces apoptosis in neuroblastoma cells, Endocr.Relat.Cancer, vol. 17, issue 2, pp. 399-414.

Le Dévédec, S.E., Lalai, R., Pont, C., Bont, H.d., van Water, B.d. , Two-photon intravital multicolor imaging combined with inducible gene expression to distinguish metastatic behavior of breast cancer cells in vivo, Mol. Imaging Biol., vol. 13, issue 1, pp. 67-77.

Verissimo, C.S., Molenaar, J.J., Meerman, J., Puigvert, J.C., Lamers, F., Koster, J., Danen, E.H., van de Water, B., Versteeg, R., Fitzsimons, C.P., Vreugdenhil, E. , Silencing of the microtubule-associated proteins doublecortin-like and doublecortin-like kinase-long induces apoptosis in neuroblastoma cells, Endocr Relat Cancer, vol. 17, no. 2, pp. 399-414.

2009

van Miltenburg, M.H., Lalai, R., de Bont, H., van Waaij, E., Beggs, H., Danen, E.H., van de Water, B. , Complete focal adhesion kinase deficiency in the mammary gland causes ductal dilation and aberrant branching morphogenesis through defects in Rho kinase-dependent cell contractility, FASEB J, vol. 23, no. 10, pp. 3482-93.

Le Dévédec, S.E., van Roosmalen, W., Maria, N., Grimbergen, M., Pont, C., Lalai, R., van de Water, B. , An improved model to study tumor cell autonomous metastasis programs using MTLn3 cells and the Rag2(-/-) gammac (-/-) mouse, Clin Exp Metastasis.

Happe, H., Leonhard, W.N., van der Wal, A., van de Water, B., Lantinga-van Leeuwen, I.S., Breuning, M.H., de Heer, E., Peters, D.J. , Toxic tubular injury in kidneys from Pkd1-deletion mice accelerates cystogenesis accompanied by dysregulated planar cell polarity and canonical Wnt signaling pathways, Hum Mol Genet, vol. 18, no. 14, pp. 2532-42.

Boesten, L.S., Zadelaar, A.S., van Nieuwkoop, A., Hu, L., Teunisse, A.F., Jochemsen, A.G., Evers, B., van de Water, B., Gijbels, M.J., van Vlijmen, B.J., Havekes, L.M., de Winther, M.P. , Macrophage p53 controls macrophage death in atherosclerotic lesions of Apolipoprotein E deficient mice, Atherosclerosis, vol. 207, no. 2, pp. 399-404.

Puigvert, J.C., Huveneers, S., Fredriksson, L., op het Veld, M., van de Water, B., Danen, E.H. , Cross-talk between integrins and oncogenes modulates chemosensitivity, Mol Pharmacol, vol. 75, no. 4, pp. 947-55.

Yan, K., Le Dévédec, S.E., Van de Water, B., Verbeek, F.J. , Cell Tracking and Data Analysis of in vitro Tumour Cells from Time-Lapse Image Sequences, Proceedings VISAPP, vol. 1, pp. 281-287.

Ma, Y., Van de Water, B., Le Dévédec, S.E. , Focal Adhesion Kinase (FAK) inhibition as a potential strategy for anticancer therapies, Drugs of the Future, vol. 34, issue 6, pp. 477-483.

2008

de Heer, P., Koudijs, M.M., van de Velde, C.J., Aalbers, R. I, Tollenaar, R.A., Putter, H., Morreau, J., van de Water, B., Kuppen, P.J. , Combined expression of the non-receptor protein tyrosine kinases FAK and Src in primary colorectal cancer is associated with tumor recurrence and metastasis formation, Eur J Surg Oncol, vol. 34, no. 11, pp. 1253-61.

Huveneers, S., Arslan, S., van de Water, B., Sonnenberg, A., Danen, E.H. , Integrins uncouple Src-induced morphological and oncogenic transformation, J Biol Chem, vol. 283, no. 19, pp. 13243-51.

Hamdi, M., Popeijus, H.E., Carlotti, F., Janssen, J.M., van der Burgt, C., Cornelissen-Steijger, P., van de Water, B., Hoeben, R.C., Matsuo, K., van Dam, H. , ATF3 and Fra1 have opposite functions in JNK- and ERK-dependent DNA damage responses, DNA Repair (Amst), vol. 7, no. 3, pp. 487-96.

de Graauw, M., Tijdens, I, Smeets, M.B., Hensbergen, P.J., Deelder, A.M., van de Water, B. , Annexin A2 phosphorylation mediates cell scattering and branching morphogenesis via cofilin Activation, Mol Cell Biol, vol. 28, no. 3, pp. 1029-40.

2007

van Nimwegen, M.J., van de Water, B. , Focal adhesion kinase: a potential target in cancer therapy, Biochem Pharmacol, vol. 73, no. 5, pp. 597-609.

de Graauw, M., Le Dévédec, S., Tijdens, I, Smeets, M.B., Deelder, A.M., van de Water, B. , Proteomic analysis of alternative protein tyrosine phosphorylation in 1,2-dichlorovinyl-cysteine-induced cytotoxicity in primary cultured rat renal proximal tubular cells, J Pharmacol Exp Ther, vol. 322, no. 1, pp. 89-100.

Alderliesten, M., de Graauw, M., Oldenampsen, J., Qin, Y., Pont, C., van Buren, L., van de Water, B. , Extracellular signal-regulated kinase activation during renal ischemia/reperfusion mediates focal adhesion dissolution and renal injury, Am J Pathol, vol. 171, no. 2, pp. 452-62.

Kruse, J.J., Svensson, J.P., Huigsloot, M., Giphart-Gassler, M., Schoonen, W.G., Polman, J.E., Jean Horbach, G., van de Water, B., Vrieling, H. , A portrait of cisplatin-induced transcriptional changes in mouse embryonic stem cells reveals a dominant p53-like response, Mutat Res, vol. 617, no. 1-2, pp. 58-70.

van Nimwegen, M.J., Verkoeijen, S., Kuppen, P.J., Velthuis, J.H., van de Water, B. , An improved method to study NK-independent mechanisms of MTLn3 breast cancer lung metastasis, Clin Exp Metastasis, vol. 24, no. 5, pp. 379-87.

2006

van Nimwegen, M.J., Huigsloot, M., Camier, A., Tijdens, I.B., van de Water, B. , Focal adhesion kinase and protein kinase B cooperate to suppress doxorubicin-induced apoptosis of breast tumor cells, Mol Pharmacol, vol. 70, no. 4, pp. 1330-9.

Boesten, L.S., Zadelaar, A.S., van Nieuwkoop, A., Hu, L., Jonkers, J., van de Water, B., Gijbels, M.J., van der Made, I, de Winther, M.P., Havekes, L.M., van Vlijmen, B.J. , Macrophage retinoblastoma deficiency leads to enhanced atherosclerosis development in ApoE-deficient mice, FASEB J, vol. 20, no. 7, pp. 953-5.

van de Water, B., de Graauw, M., Le Dévédec, S., Alderliesten, M. , Cellular stress responses and molecular mechanisms of nephrotoxicity, Toxicol Lett, vol. 162, no. 1, pp. 83-93.

Lombaerts, M., van Wezel, T., Philippo, K., Dierssen, J.W., Zimmerman, R.M., Oosting, J., van Eijk, R., Eilers, P.H., van de Water, B., Cornelisse, C.J., Cleton-Jansen, A.M. , E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines, Br J Cancer, vol. 94, no. 5, pp. 661-71.

de Graauw, M., Hensbergen, P., van de Water, B. , Phospho-proteomic analysis of cellular signaling, Electrophoresis, vol. 27, no. 13, pp. 2676-86.

Burg, D., Riepsaame, J., Pont, C., Mulder, G., van de Water, B. , Peptide-bond modified glutathione conjugate analogs modulate GSTpi function in GSH-conjugation, drug sensitivity and JNK signaling, Biochem Pharmacol, vol. 71, no. 3, pp. 268-77.

2005

van Nimwegen, M.J., Verkoeijen, S., van Buren, L., Burg, D., van de Water, B. , Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation, Cancer Res, vol. 65, no. 11, pp. 4698-706.

de Graauw, M., Tijdens, I, Cramer, R., Corless, S., Timms, J.F., van de Water, B. , Heat shock protein 27 is the major differentially phosphorylated protein involved in renal epithelial cellular stress response and controls focal adhesion organization and apoptosis, J Biol Chem, vol. 280, no. 33, pp. 29885-98.

2004

Imamdi, R., de Graauw, M., van de Water, B. , Protein kinase C mediates cisplatin-induced loss of adherens junctions followed by apoptosis of renal proximal tubular epithelial cells, J Pharmacol Exp Ther, vol. 311, no. 3, pp. 892-903.

2003

Huigsloot, M., Tijdens, R.B., van de Water, B. , Inhibition of protein kinase Calpha enhances anticancer agent-induced loss of anchorage-independent growth regardless of protection against apoptosis by Bcl-2, Mol Pharmacol, vol. 64, no. 4, pp. 965-73.

2002

Huigsloot, M., Tijdens, I.B., Mulder, G.J., van de Water, B. , Differential regulation of doxorubicin-induced mitochondrial dysfunction and apoptosis by Bcl-2 in mammary adenocarcinoma (MTLn3) cells, J Biol Chem, vol. 277, no. 39, pp. 35869-79.

Nauta, A.J., Daha, M.R., Tijsma, O., van de Water, B., Tedesco, F., Roos, A. , The membrane attack complex of complement induces caspase activation and apoptosis, Eur J Immunol, vol. 32, no. 3, pp. 783-92.

Leussink, B.T., Nagelkerke, J.F., van de Water, B., Slikkerveer, A., van der Voet, G.B., Srinivasan, A., Bruijn, J.A., de Wolff, F.A., de Heer, E. , Pathways of proximal tubular cell death in bismuth nephrotoxicity, Toxicol Appl Pharmacol, vol. 180, no. 2, pp. 100-9.

2001

van de Water, B., Houtepen, F., Huigsloot, M., Tijdens, I.B. , Suppression of chemically induced apoptosis but not necrosis of renal proximal tubular epithelial (LLC-PK1) cells by focal adhesion kinase (FAK). Role of FAK in maintaining focal adhesion organization after acute renal cell injury, J Biol Chem, vol. 276, no. 39, pp. 36183-93.

Huigsloot, M., Tijdens, I.B., Mulder, G.J., van de Water, B. , Differential regulation of phosphatidylserine externalization and DNA fragmentation by caspases in anticancer drug-induced apoptosis of rat mammary adenocarcinoma MTLn3 cells, Biochem Pharmacol, vol. 62, no. 8, pp. 1087-97.

van Vlijmen, B.J., Gerritsen, G., Franken, A.L., Boesten, L.S., Kockx, M.M., Gijbels, M.J., Vierboom, M.P., van Eck, M., van De Water, B., van Berkel, T.J., Havekes, L.M. , Macrophage p53 deficiency leads to enhanced atherosclerosis in APOE*3-Leiden transgenic mice, Circ Res, vol. 88, no. 8, pp. 780-6.

2000

Stevens, J.L., Liu, H., Halleck, M., Bowes, R.C., Chen, Q.M., van de Water, B. , Linking gene expression to mechanisms of toxicity, Toxicol Lett, vol. 112-113, pp. 479-86.

van de Water, B., Tijdens, I.B., Verbrugge, A., Huigsloot, M., Dihal, A.A., Stevens, J.L., Jaken, S., Mulder, G.J. , Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells, J Biol Chem, vol. 275, no. 33, pp. 25805-13.

1999

van De Water, B., Wang, Y., Asmellash, S., Liu, H., Zhan, Y., Miller, E., Stevens, J.L. , Distinct endoplasmic reticulum signaling pathways regulate apoptotic and necrotic cell death following iodoacetamide treatment, Chem Res Toxicol, vol. 12, no. 10, pp. 943-51.

Zhan, Y., van de Water, B., Wang, Y., Stevens, J.L. , The roles of caspase-3 and bcl-2 in chemically-induced apoptosis but not necrosis of renal epithelial cells, Oncogene, vol. 18, no. 47, pp. 6505-12.

van de Water, B., Nagelkerke, J.F., Stevens, J.L. , Dephosphorylation of focal adhesion kinase (FAK) and loss of focal contacts precede caspase-mediated cleavage of FAK during apoptosis in renal epithelial cells, J Biol Chem, vol. 274, no. 19, pp. 13328-37.

Bowes, R.C., Lightfoot, R.T., Van De Water, B., Stevens, J.L. , Hepatocyte growth factor induces tubulogenesis of primary renal proximal tubular epithelial cells, J Cell Physiol, vol. 180, no. 1, pp. 81-90.

1998

Liu, H., Miller, E., van de Water, B., Stevens, J.L. , Endoplasmic reticulum stress proteins block oxidant-induced Ca2+ increases and cell death, J Biol Chem, vol. 273, no. 21, pp. 12858-62.

Kruidering, M., van de Water, B., Zhan, Y., Baelde, J.J., Heer, E., Mulder, G.J., Stevens, J.L., Nagelkerke, J.F. , Cisplatin effects on F-actin and matrix proteins precede renal tubular cell detachment and apoptosis in vitro, Cell Death Differ, vol. 5, no. 7, pp. 601-14.

Fowler, L., Dong, L., Bowes, R.C., van de Water, B., Stevens, J.L., Jaken, S. , Transformation-sensitive changes in expression, localization, and phosphorylation of adducins in renal proximal tubule epithelial cells, Cell Growth Differ, vol. 9, no. 2, pp. 177-84.

1997

Kruidering, M., Van de Water, B., de Heer, E., Mulder, G.J., Nagelkerke, J.F. , Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain, J Pharmacol Exp Ther, vol. 280, no. 2, pp. 638-49.

Liu, H., Bowes, R.C., van de Water, B., Sillence, C., Nagelkerke, J.F., Stevens, J.L. , Endoplasmic reticulum chaperones GRP78 and calreticulin prevent oxidative stress, Ca2+ disturbances, and cell death in renal epithelial cells, J Biol Chem, vol. 272, no. 35, pp. 21751-9.

1996

Andreadou, I, van de Water, B., Commandeur, J.N., Nagelkerke, F.J., Vermeulen, N.P. , Comparative cytotoxicity of 14 novel selenocysteine se-conjugates in rat renal proximal tubular cells, Toxicol Appl Pharmacol, vol. 141, no. 1, pp. 278-87.

van de Water, B., Zoeteweij, J.P., Nagelkerke, J.F. , Alkylation-induced oxidative cell injury of renal proximal tubular cells: involvement of glutathione redox-cycle inhibition, Arch Biochem Biophys, vol. 327, no. 1, pp. 71-80.

Van de Water, B., Kruidering, M., Nagelkerke, J.F. , F-actin disorganization in apoptotic cell death of cultured rat renal proximal tubular cells, Am J Physiol, vol. 270, no. 4 Pt 2, pp. F593-603.

Zoetewij, J.P., van de Water, B., de Bont, H.J., Nagelkerke, J.F. , The role of a purinergic P2z receptor in calcium-dependent cell killing of isolated rat hepatocytes by extracellular adenosine triphosphate, Hepatology, vol. 23, no. 4, pp. 858-65.

Kruidering, M., van de Water, B., Nagelkerke, J.F. , Methods for studying renal toxicity, Arch Toxicol Suppl, vol. 18, pp. 173-83.

1995

van de Water, B., Zoeteweij, J.P., de Bont, H.J., Nagelkerke, J.F. , Inhibition of succinate:ubiquinone reductase and decrease of ubiquinol in nephrotoxic cysteine S-conjugate-induced oxidative cell injury, Mol Pharmacol, vol. 48, no. 5, pp. 928-37.

1994

Van de Water, B., Jaspers, J.J., Maasdam, D.H., Mulder, G.J., Nagelkerke, J.F. , In vivo and in vitro detachment of proximal tubular cells and F-actin damage: consequences for renal function, Am J Physiol, vol. 267, no. 5 Pt 2, pp. F888-99.

van de Water, B., Zoeteweij, J.P., de Bont, H.J., Mulder, G.J., Nagelkerke, J.F. , Role of mitochondrial Ca2+ in the oxidative stress-induced dissipation of the mitochondrial membrane potential. Studies in isolated proximal tubular cells using the nephrotoxin 1,2-dichlorovinyl-L-cysteine, J Biol Chem, vol. 269, no. 20, pp. 14546-52.

van de Water, B., van Berkel, T.J., Kuiper, J. , Activation of rat Kupffer cells to tumoricidal cells by the immunomodulator muramyl tripeptide-phosphatidylethanolamine incorporated into the novel drug carrier lactosylated low density lipoprotein, Mol Pharmacol, vol. 45, no. 5, pp. 971-7.

Zoeteweij, J.P., van de Water, B., de Bont, H.J., Nagelkerke, J.F. , Mitochondrial K+ as modulator of Ca(2+)-dependent cytotoxicity in hepatocytes. Novel application of the K(+)-sensitive dye PBFI (K(+)-binding benzofuran isophthalate) to assess free mitochondrial K+ concentrations, Biochem J, vol. 299 ( Pt 2, pp. 539-43.

1993

van de Water, B., Zoetewey, J.P., de Bont, H.J., Mulder, G.J., Nagelkerke, J.F. , The relationship between intracellular Ca2+ and the mitochondrial membrane potential in isolated proximal tubular cells from rat kidney exposed to the nephrotoxin 1,2-dichlorovinyl-cysteine, Biochem Pharmacol, vol. 45, no. 11, pp. 2259-67.

Zoeteweij, J.P., van de Water, B., de Bont, H.J., Mulder, G.J., Nagelkerke, J.F. , Calcium-induced cytotoxicity in hepatocytes after exposure to extracellular ATP is dependent on inorganic phosphate. Effects on mitochondrial calcium, J Biol Chem, vol. 268, no. 5, pp. 3384-8.

1992

Zoeteweij, J.P., van de Water, B., de Bont, H.J., Mulder, G.J., Nagelkerke, J.F. , Involvement of intracellular Ca2+ and K+ in dissipation of the mitochondrial membrane potential and cell death induced by extracellular ATP in hepatocytes, Biochem J, vol. 288 ( Pt 1, pp. 207-13.

1991

Nagelkerke, J.F., van de Water, B., Twiss, I.M., Zoetewey, J.P., de Bont, H.J., Dogterom, P., Mulder, G.J. , Role of microtubuli in secretion of very-low-density lipoprotein in isolated rat hepatocytes: early effects of thiol reagents, Hepatology, vol. 14, no. 6, pp. 1259-68.

Bob van de Water teaches or supervises the following courses:

• Theme Effects of drugs III – Drug Safety Evaluation
• Signal transduction: from target discovery to therapy
• Post Doctoral Course "Cell Toxicology"
• Post-Doctoral: "Cellular Toxicology/Predictive Toxicology" - IMI-SafeSciMET Training Programme in Safety Sciences

Bob currently supervises the following students:

• Kuan Yuan
• Michiel Fokkelman
• Steven Wink
• Maria Rogkoti
• Yu Qin

Projects supervised by Bob van de Water: